Textify afterfx3/17/2023 ![]() ![]() ![]() Studies were evaluated using the Cochrane Collaboration's risk of bias tool adapted to environmental sciences. We included studies evaluating the association between low-to-moderate IR doses received during gestation, childhood and adolescence, and neurodevelopmental functions. Searches were performed in PubMed, Scopus, EMBASE and Psychinfo on the 6th of June 2017 and repeated in December 2018. We conducted a systematic review of the current evidence for possible effects of low-to-moderate IR doses received during gestation, childhood and adolescence on different domains of neurodevelopment. Considering the increasing exposure of the general population to low-to-moderate levels of IR, predominantly from diagnostic procedures, the study of these effects has become a priority for radiation protection. To what extent such effects exist at low-to-moderate doses is unclear. The neurodevelopmental effects of high doses of ionizing radiation (IR) in children are well established. A follow-up study of the children irradiated in utero, who may be at risk for schizophrenia, is proposed because of its particular importance to clinical medicine and neuroscience. ![]() The data obtained reveal mental disorders in prenatally irradiated children and obviously reflect developmental abnormalities of brain structure and function as a result of the interaction of prenatal and post-natal factors where it is possible to assume radiation effects on the developing brain. We hypothesize that the cerebral basis of mental disorders in the prenatally irradiated children is the malfunction of the left hemisphere limbic-reticular structures, particularly in those exposed at the most critical period of cerebrogenesis (8-25 weeks of gestation). One important biological mechanism in the genesis of mental disorders in prenatally irradiated children is the radiation-induced malfunction of the thyroid-pituitary system with the effect threshold of 0.30 Sv of thyroid exposure dose. We found a significant increase in mental retardation (IQ 110) in children irradiated in utero as a result of the Chernobyl disaster, in comparison with the controls. At this phase clinical examinations, psychometric tests, computerized EEG, thyroid function assessment and dosimetric reconstruction were used. Further, we randomly selected 50 prenatally irradiated children whose mothers were evacuated from the Chernobyl exclusion zone and 50 age-and-gender-matched non-exposed children. The control group of relevant children (n = 759), their mothers and teachers, were living at the radioecological 'clear' regions (Kharkov and Kharkov Region). Prenatally irradiated children (n = 544), who were born between 26 April 1986 and 26 February 1987, in regions of the Ukraine which were radioactively contaminated as a result of the Chernobyl disaster, their mothers and teachers have been examined with psychometric tests. ![]()
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